Five of six treated kittens experienced hypersalivation. It binds to gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels of the nerves and muscles of the parasite resulting in hyperpolarization, paralysis and death. In well-controlled laboratory studies, Bravecto Plus demonstrated ≥ 98.1% effectiveness against Ixodes scapularis 48 hours after treatment or infestation for 2 months. 0061-5997-01, Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. A second cat in the 1× group had neurologic signs that included ataxia, paresis, and muscle tremors 25 days after dosing. per page. Percentage of Cats with Adverse Reactions (AR) in the Field Study, Safety in cats infected with adult heartworm (Dirofilaria immitis), All Drug Updated: 2020-12-31. The tube is open and ready for application when a breaking of the seal is felt. For Medium Cats . Each tube is packaged individually in a pouch. If contact with eyes occurs, then flush eyes slowly and gently with water. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. Bravecto Plus Spot-on Solution for Cats is for cats with, or at risk from, mixed parasitic infestations by ticks and fleas, gastrointestinal nematodes or heartworm. Get Label RSS Feed, * Cats over 27.5 lb should be administered the appropriate combination of tubes. The safety of BRAVECTO PLUS has not been established in breeding, pregnant and lactating cats. The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2- trifluoroethylamino) ethyl]benzamide. The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. Updated is this? Files, All Mapping As I opened the packaging I split some on my hands. Treated kittens had reduced food consumption on the day of treatment. For Large Cats . Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. Reg. SAVE MORE WITH BRAVECTO ®. Fluralaner is an inhibitor of the arthropod nervous system. Biochemical Data Summary. Percentage of Cats with Adverse Reactions (AR) in the Field Study, Bravecto Plus Group: Percent of Cats with the AR During the 120-Day Study (n=135 cats), Active Control Group: Percent of Cats with the AR During the 120-Day Study (n=41 cats). Oral Safety Studies: In an oral safety study, one dose of Bravecto Plus was administered orally to 4- to 9-month-old kittens at the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg. FOR EXTERNAL ANIMAL USE ONLY . 3 doses of BRAVECTO® per pet, get a rebate of $20; 4 doses of BRAVECTO® per pet, get a rebate of $30. Product may be supplied in 1 or 2 tubes per carton. should be administered the appropriate combination of tubes. Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat's first seasonal exposure to mosquitoes and continuing until the cat's last seasonal exposure to mosquitoes. Field Safety Study: In a well-controlled field study, Bravecto Plus was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics and steroids. Bravecto Plus has not been shown to be effective in kittens less than 6 months of age. Each tube is packaged individually in a pouch. They are available in three weight range packs, with a simple twist-n-use dispensing tube making it quick and easy to use. In well-controlled laboratory studies, Bravecto Plus was effective against naturally and experimentally induced adult and experimentally induced 4th stage larval and immature adult Toxocara cati and Ancylostoma tubaeforme infections in cats. BRAVECTO PLUS- fluralaner and moxidectin solution. Compare. In two well-controlled laboratory studies, Bravecto Plus was 100% effective against induced heartworm infections when administered 2 months prior to infection. Each tube is formulated to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. After applying Bravecto for Cats, the medication quickly reaches tissue fluids under your cat's skin. One cat exhibited transient lacrimation from one eye during the first 15 minutes after dosing. Contents: 1 tube containing 250 mg fluralaner and 12.5 mg moxidectin Approved by FDA under NADA # 141-518, For cats and kittens 6 months of age and older How to apply Bravecto Topical for cats: Step 1: removing the tube from the product pouch, and holding the tube firmly upright you twist the cap of the tube off until you hear the seal breaking. If contact with eyes occurs, then flush eyes slo… Single incidences of self-limiting hypersalivation in three kittens (one kitten in the 1X group and two kittens in the 3X group) and pruritus at the administration site in one kitten in the 3X group were observed on the day of dose administration. Each tube is packaged individually in a pouch. WARNINGS Human Warnings: Not for human use. When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one month of the last dose of the former medication. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis), gross pathology, histopathology, or organ weights. A cat in the 3X group exhibited depression, dehydration, a hunched position, and inability to stand 22 days after dosing. Part the hair and apply directly to the skin. One stop treatment shop for dogs and cats to prevent nasty parasites from damaging their health. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Bravecto for Cats requires a prescription from your veterinarian. There are no known contraindications for the use of the product. Moxidectin is for systemic use and is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones. Do not contact or allow children to contact the application site until 2 hours post application. For topical use only. Copy the URL below and paste it into your RSS Reader application. When fleas and ticks feed on your cat, they ingest Bravecto for Cats and die. Bravecto for Cats is available in three strengths for use in cats (112.5 mg, 250 mg, and 500 mg fluralaner per tube). Contents: 1 tube containing 500 mg fluralaner and 25 mg moxidectin Approved by FDA under NADA # 141-518, Report Adverse Events (Animal Drug), Do not contact or allow children to contact the application site until 2 hours post application. The seal was broken on the first pack of Bravecto Plus for cats I purchased. The cap should be rotated clockwise or counter clockwise one full turn. * 3 Cats over 27.5 lb. Bravecto for Cats; Bravecto for Cats. In foreign market experience reports for Bravecto Plus, one veterinarian experienced tingling and numbness of the fingers, hand, and arm, and swelling of the hand and arm after getting Bravecto Plus on her fingers. Drug names that are ambiguous or not compatible with the RxNorm system, such as multivitamins with more than 4,000 characters in their names, are also out of scope. Put on gloves. Avoid oral ingestion. There are no known contraindications for the use of the product. How to use Bravecto Plus for Cats Ensure the animal's back is horizontal. I live in New Zealand I used this on my three cats today. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. Additional information can be found at www.bravecto.com. Bravecto Plus - How it works? Keep away from heat, sparks, open flame or other sources of ignition. 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