Side Effects What are the side effects of Sulfasalazine (Azulfidine)?. These negative effects might evaporate as the body gets used to the medication. The most common side effects include: Upset stomach; Diarrhea; Nausea/vomiting; Headache; Appetite loss; Skin sensitivity; Approximately 10% of patients taking Sulfasalazine experience a skin rash. The most common side effects are nausea or abdominal discomfort. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Sulfasalazine may cause blood problems. Sulfasalazine causes temporary infertility in males. What should I watch for? The Sulphasalazine is a DMARD and this can effect the white blood cells, sometimes they will withdraw the Dmard and try another one. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. But I think it must be - after all, side effects are only known by getting feedback from the people using the drug. You will need frequent blood and urine checks. He has decided to stay on the same dose rather than increase it to see if it stabilises. !!! Oh, my GP said the itching wasnt a side effect of sulfazal. He's tried a couple of other tablets but had to stop those due to side effects such as blisters etc. Keep out of the sun. What are some other side effects of Sulfasalazine Tablets? Stomach pain or heartburn. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Fertility returns when the medicine is stopped. I had this problem about twenty years ago. It is best to take this medicine right after meals, at evenly spaced times throughout the day and night. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. I hope it settles down for you and works well for your RA. Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. However, many people have no side effects or only have minor side effects. All drugs may cause side effects. Certainly it went away when i stopped taking it. In rheumatoid arthritis, the effect of sulfasalazine delayed release tablets can be assessed by the degree of improvement in the number and extent of actively inflamed joints. Some side effects that are sulfasalazine might not require any medical attention. Visit your doctor or health care professional for regular checks on your progress. Side effects include dry eye, decreased appetite, vomiting, yellowing of the skin, eyes, or body fluids. Try not to let more than 8 … My husband started on sulfasalazine a week ago on two a day. Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. Possible Side Effects. 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